TY  - JOUR
TI  - Development of antimicrobial hydrogels for burn wound treatment
AU  - Chirila, Laura
AU  - Popescu, Alina
AU  - Ignat, Madalina
AU  - Avadanei, Manuela
AU  - Lite, Cristina Mihaela
T2  - Industria Textila
AB  - To obtain biomaterials with the potential for use in the treatment of first-burn injuries, this study focused on the
development of several polymeric systems based on collagen-polyvinyl alcohol-active principles. The hydrogels were
prepared using polymeric matrices formers (collagen and polyvinyl alcohol), water, and glycerol in the presence of the
nonionic surfactant polysorbate 80 (Tween 80®) under proper homogenization. For the development of multifunctional
textile materials designed for topical application, ciprofloxacin, chlorhexidine, tea tree essential oil, and curcumin were
used as active principles. The obtained hydrogels were then immobilized by the padding method on 100% plain weave
cotton. The functionalized textile materials were characterized in terms of their physico-mechanical and comfort
characteristics, hydrophilicity, and antibacterial activity. The mass of all the functionalized textile materials increased
compared to that of the untreated fabric, due to the amount of polymeric systems remaining after the functionalization
process. The water vapour permeability and air permeability of the functionalized materials were lower than those of the
untreated samples. Antibacterial activity was observed for all analysed samples, with inhibition zones between 14 mm
(CUC-11 code in the presence of S. aureus) and 27 mm (CUC-1 code in the presence of E. coli), obtained for the textile
materials treated with the hydrogels containing ciprofloxacin, exhibiting the most pronounced antibacterial effect
compared to analogous samples containing chlorhexidine. The obtained experimental data suggest that these hydrogels
are appropriate candidates for application in burn wound management.
DA  - 2024/04/30/
PY  - 2024
DO  - 10.35530/IT.075.02.2021113
DP  - DOI.org (Crossref)
VL  - 75
IS  - 02
SP  - 194
EP  - 202
SN  - 12225347
UR  - http://revistaindustriatextila.ro/images/2024/2/010%20LAURA%20CHIRILA%20INDUSTRIA%20TEXTILA%20no.2_2024.pdf
Y2  - 2024/05/15/06:34:31
ER  -